How are these boosters different from previous COVID-19 booster shots?

When COVID-19 was first identified, the goal was to develop vaccines that were effective against the initial “spike protein” found in the virus. Since then, several concerning variants of COVID-19 have developed, with the most recent one being the omicron variant.Variants have mutations that can evade the antibody response triggered by the initial vaccines. So, whenever a variant is introduced into the community, we have to consider whether current vaccines and boosters prevent illness and protect against severe disease caused by that variant.The current vaccines and boosters are less effective at preventing illness from omicron, but they’re holding up against development of more serious infection that leads to hospitalization, severe disease and death. The goal of the new COVID-19 boosters is to provide protection against ever getting infected with omicron in the first place.

How effective are omicron boosters?

The current COVID-19 vaccines provide protectionagainst severe disease, and individuals who are up to date on their vaccine series will have better outcomes than those who are not. The thinking with the new omicron boosters was to develop a vaccine to target the currently spreading variants and prevent infection to begin with. Effectiveness is unclear, and it will be interesting to see data on how well the omicron-specific boosters will prevent disease, and how long this protection will last.Why you shouldn’t ‘just let yourself get omicron.’

Who is eligible for an omicron booster?

The CDC has recommended that certain boosters (Pfizer) be available to anyone 12 and older while others (Moderna) be available to those 18 and older. If you’re in this age range, you’ll be able to get an omicron booster if you’ve gotten a two-shot initial series of an mRNA vaccine (Pfizer or Moderna) or a single initial shot of the Johnson & Johnson vaccine.

When should I get an omicron booster?

With COVID-19 spread happening in peaks and valleys, people should talk to their primary care doctors to find out when it’s best for them to get an omicron booster depending on how susceptible they are to developing severe disease. It should not be given until at least two months after any previous COVID-19 initial vaccine or booster.

Health

What you need to know about the new COVID-19 omicron booster

Mohammad Mahdee Sobhanie, MD

Infectious Disease Specialist, Assistant Professor
Ohio State Wexner Medical Center

September 6, 2022

A woman receives her COVID-19 omicron booster shot

Editor’s note: As what we know about COVID-19 evolves, so could the information in this story. Find our most recent COVID-19 articles here and learn the latest in COVID-19 prevention at the Centers for Disease Control and Prevention. Some photos and videos on this site were filmed prior to the COVID-19 outbreak or may not reflect current physical distancing and/or masking guidelines.

You may be wondering about the updated COVID-19 boosters recently authorized by the U.S. Food and Drug Administration and recommended by the Centers for Disease Control and Prevention. Here, I answer some common questions about the boosters.

Question How are these boosters different from previous COVID-19 booster shots?: Answer
When COVID-19 was first identified, the goal was to develop vaccines that were effective against the initial “spike protein” found in the virus. Since then, several concerning variants of COVID-19 have developed, with the most recent one being the omicron variant.

Variants have mutations that can evade the antibody response triggered by the initial vaccines. So, whenever a variant is introduced into the community, we have to consider whether current vaccines and boosters prevent illness and protect against severe disease caused by that variant.

The current vaccines and boosters are less effective at preventing illness from omicron, but they’re holding up against development of more serious infection that leads to hospitalization, severe disease and death. The goal of the new COVID-19 boosters is to provide protection against ever getting infected with omicron in the first place.
Question How effective are omicron boosters?: Answer
The current COVID-19 vaccines provide protection against severe disease, and individuals who are up to date on their vaccine series will have better outcomes than those who are not. The thinking with the new omicron boosters was to develop a vaccine to target the currently spreading variants and prevent infection to begin with. Effectiveness is unclear, and it will be interesting to see data on how well the omicron-specific boosters will prevent disease, and how long this protection will last.

Why you shouldn’t ‘just let yourself get omicron.’
Question Who is eligible for an omicron booster?: Answer
The CDC has recommended that certain boosters (Pfizer) be available to anyone 12 and older while others (Moderna) be available to those 18 and older. If you’re in this age range, you’ll be able to get an omicron booster if you’ve gotten a two-shot initial series of an mRNA vaccine (Pfizer or Moderna) or a single initial shot of the Johnson & Johnson vaccine.
Question When should I get an omicron booster?: Answer
With COVID-19 spread happening in peaks and valleys, people should talk to their primary care doctors to find out when it’s best for them to get an omicron booster depending on how susceptible they are to developing severe disease. It should not be given until at least two months after any previous COVID-19 initial vaccine or booster.